PAETE.ORG FORUMS
Paetenians Home on the Net

HOME | ABOUT PAETE | USAP PAETE MUNISIPYO  | MEMBERS ONLY  | PICTORIAL PAETE | SINING PAETE  | LINKS  |

FORUM GUIDELINES
please read before posting

USAP PAETE Forum Index USAP PAETE
Discussion Forums for the people of Paete, Laguna, Philippines
 
 FAQFAQ   SearchSearch    UsergroupsUsergroups   RegisterRegister 
 ProfileProfile   Log in to check your private messagesLog in to check your private messages   Log inLog in 

(Health) Gout Increases Risk of Heart Attack

 
Post new topic   Reply to topic   printer-friendly view    USAP PAETE Forum Index -> Science Lessons Forum
View previous topic :: View next topic  
Author Message
adedios
SuperPoster


Joined: 06 Jul 2005
Posts: 5060
Location: Angel C. de Dios

PostPosted: Wed Aug 02, 2006 10:01 am    Post subject: (Health) Gout Increases Risk of Heart Attack Reply with quote






University of Pittsburgh Medical Center
2 August 2006

Gout increases risk of heart attack, according to University of Pittsburgh study

Pittsburgh, Aug. 2 -- People with gout are at increased risk of having a heart attack, according to a University of Pittsburgh School of Medicine study published in the August edition of the journal Arthritis & Rheumatism. The article is available on line at http://www3.interscience.wiley.....e/76509746 . This is the first study to show that among men with no previous history of coronary artery disease, gout is a significant independent risk factor of heart attack.

Gout is a metabolic disease marked by acute arthritis and inflammation of the joints, usually beginning in the knee or foot. It is caused by hyperuricemia, a build up of uric acid in blood. When chronic or severe hyperuricemia leads to urate crystals within joints, it results in an inflammatory response that manifests as gouty arthritis.

"Our study confirms that gouty arthritis is an independent risk factor for myocardial infarction (MI) or heart attack. Until now this relationship has not been explained by well-known links to renal function, metabolic syndrome, diuretic use and the traditional cardiovascular risk factors," said Eswar Krishnan, M.D., assistant professor of medicine at the University of Pittsburgh School of Medicine, division of rheumatology, and principal author of the study.

The prospective study examined data from 12,866 men who were enrolled for a mean of 6.5 years in the Multiple Risk Factor Intervention Trial (MRFIT), a randomized primary cardiovascular disease prevention trial conducted and supported by the National Heart, Lung and Blood Institute.

There were 5,337 men with hyperuricemia at the beginning of the study. Over the study period, 1,123 individuals developed gouty arthritis. There was no statistically significant difference between the groups with regard to cholesterol levels, aspirin use, family history of acute MI, or diabetes mellitus. However, the group with gout was significantly more likely to have used diuretics and alcohol. Modest yet statistically significant elevations of blood pressure, age, blood glucose and body mass index were observed in the gout group. Subjects in the group with gout were less likely to be current smokers than were those in the group without gout.

During the course of the study, 1,108 events of acute MI occurred in the group with gout (10.5 percent) and 990 events in the group without gout (8.43 percent). Of the 1,108 MIs, 246 were fatal.

The study also found a relationship between gout and the risk of acute MI to be present among nonusers of alcohol, diuretics or aspirin and among those who did not have metabolic syndrome, diabetes mellitus or obesity.

"The absolute magnitude of the relative risk for the presence of gout was not high. Yet, the odds ratio associated with gout was relatively high compared to other risk factors in this study," Dr. Krishnan said. "For acute MI to occur, an environment that promotes atherogenesis and thrombogenesis is needed. Hyperuricemia is well known to be an independent risk factor for atherosclerotic diseases in general and since chronic hyperuricemia is strongly associated with gout, it is not very surprising that an independent coronary risk for the presence of both hyperuricemia and gout was observed."


###
This study was supported by an unrestricted grant from TAP Pharmaceutical Products Inc. of Lake Forest, Il. This was an investigator-initiated project, and TAP Pharmaceutical Products Inc. was not involved in the design, data collection, or analysis and interpretation of the data.

*************************************************************

Related topics:

Crystals

http://www.paete.org/forums/viewtopic.php?t=1178

Heart Diseases

http://www.paete.org/forums/viewtopic.php?t=1875

DNA

http://www.paete.org/forums/viewtopic.php?t=1353

RNA

http://www.paete.org/forums/viewtopic.php?t=2019

Proteins

http://www.paete.org/forums/viewtopic.php?t=1365

The Circulatory System

http://www.paete.org/forums/viewtopic.php?t=843

Arthritis

http://www.paete.org/forums/viewtopic.php?t=1582

*************************************************************

Questions to explore further this topic:

What is gout?

http://www.umm.edu/patiented/a.....000478.htm
http://www.animatedmedical.com/Gout/Gout.html
http://www.niams.nih.gov/hi/topics/gout/gout.htm
http://www.mayoclinic.com/health/gout/DS00090
http://www.arc.org.uk/about_ar.....5/6015.htm
http://www.medicinenet.com/gout/article.htm
http://www.arthritis.org/condi.....r/gout.asp
http://www.jr2.ox.ac.uk/bandol.....tintr.html
http://www.umm.edu/patiented/a.....0093_1.htm

What causes gout?

http://www.umm.edu/patiented/a.....0093_2.htm

What are the symptoms of gout?

http://www.umm.edu/patiented/a.....0093_3.htm

How serious is gout?

http://www.umm.edu/patiented/a.....0093_4.htm

What are the risk factors for gout?

http://www.umm.edu/patiented/a.....0093_5.htm

How is gout diagnosed?

http://www.umm.edu/patiented/a.....0093_6.htm

What are the general guidelines for treating gout?

http://www.umm.edu/patiented/a.....0093_7.htm

How is gout medicated?

http://www.umm.edu/patiented/a.....0093_8.htm

What lifestyle measures can be taken to avoid gout?

http://www.umm.edu/patiented/a.....0093_9.htm

What is pseudogout?

http://www.merck.com/mmhe/sec05/ch070/ch070c.html

What is uric acid?

http://en.wikipedia.org/wiki/Uric_acid
http://www.agora.crosemont.qc......oc_026.htm

What are uric acid crystals?

http://www.academic.marist.edu.....ine42.html

What is a uric acid test?

http://www.labtestsonline.org/...../test.html
http://www.nlm.nih.gov/medline.....003476.htm

What are nucleic acids?

http://www.visionlearning.com/.....php?mid=63

What are purines?

http://en.wikipedia.org/wiki/Purine

What foods are high in purine content?

http://www.marinurology.com/ar.....urines.htm

What are pyrimidines?

http://en.wikipedia.org/wiki/Pyrimidine

The chemistry and metabolism of nucleic acids, purines and pyrimidines

http://arjournals.annualreview.....135.001125

What is urinalysis?

http://media.lakeareatech.edu/...../frame.htm
http://medsci.indiana.edu/c602.....ntroa.html

GAMES

http://www.familyfoodzone.com/.....s-main.asp
http://www.familyfoodzone.com/.....active.asp
Back to top
View user's profile Send private message Visit poster's website
Display posts from previous:   
Post new topic   Reply to topic   printer-friendly view    USAP PAETE Forum Index -> Science Lessons Forum All times are GMT - 5 Hours
Page 1 of 1

 
Jump to:  
You can post new topics in this forum
You can reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum


Powered by phpBB © 2001, 2005 phpBB Group